Diclofenac Omeprazol

This combination product pairs diclofenac (an NSAID for pain and inflammation) with omeprazole (a proton pump inhibitor for stomach protection). It is prescribed for patients who need regular NSAID therapy but are at increased risk of gastrointestinal complications such as peptic ulcers and GI bleeding. The omeprazole component protects the stomach lining from the ulcerogenic effects of diclofenac.

How to Take Diclofenac/Omeprazole

Diclofenac/omeprazole combination tablets are taken once or twice daily, depending on the formulation and your doctor's instructions. Swallow the tablet whole — do not crush, break, or chew it, as this disrupts the modified-release coating and the separation of the two active ingredients. Take with food or immediately after a meal.

The combination is designed for people who need an NSAID for pain or inflammation but are at higher risk of stomach complications — the omeprazole component protects the stomach lining while the diclofenac provides anti-inflammatory pain relief.

Duration of Use

Use the lowest effective dose for the shortest time needed. Regular review by your doctor is important for ongoing prescriptions. Do not take additional NSAIDs or aspirin (at anti-inflammatory doses) alongside this combination without medical advice, as this increases gastrointestinal risk without added benefit.

Typical dose: diclofenac 75 mg / omeprazole 20 mg, one tablet twice daily. The exact formulation and dose depend on the brand and clinical indication.

Common Side Effects

• Headache
• Nausea or stomach discomfort
• Abdominal pain
• Diarrhoea or constipation
• Dizziness
• Flatulence

Cardiovascular and Kidney Risks

Diclofenac carries a small increased risk of heart attack and stroke, particularly at higher doses or with prolonged use. This risk is higher than with some other NSAIDs (ibuprofen, naproxen) and the combination should be used with caution in people with heart disease, hypertension, or kidney problems. Tell your doctor if you develop ankle swelling, reduced urine output, or persistent high blood pressure during treatment. Kidney function may need monitoring with long-term use, particularly in older patients or those taking diuretics or ACE inhibitors.

While gastroprotection reduces GI risk, it does not eliminate it entirely. Use the lowest effective dose for the shortest duration. The cardiovascular risks of diclofenac remain unchanged by the addition of omeprazole.

Contraindicated in active peptic ulceration, severe heart failure, severe hepatic or renal impairment, third trimester of pregnancy, and known NSAID or aspirin allergy.