Gliclazid MR

Gliclazide is a sulphonylurea for type 2 diabetes, available as immediate-release tablets and modified-release (MR) formulations. The generic version provides the same glucose-lowering effect as branded Diamicron. Gliclazide stimulates insulin secretion from functioning beta cells and has antioxidant properties that may help preserve beta cell function over time.

How to Take Gliclazide

Take gliclazide with breakfast or the first meal of the day. For modified-release (MR) tablets, swallow whole, do not crush, break, or chew them. The MR formulation is taken once daily, while standard tablets may be taken once or twice daily depending on the dose your doctor prescribes.

Monitor your blood glucose regularly and be alert for signs of hypoglycaemia (low blood sugar), including shakiness, sweating, confusion, and rapid heartbeat. Carry glucose tablets or a sugary snack with you in case your blood sugar drops. Do not skip meals while taking this medication.

Immediate-release: 40 to 320 mg daily in divided doses. MR: 30 to 120 mg once daily with breakfast.

Common Side Effects

Common side effects include:

• Hypoglycaemia (low blood sugar), the most important risk. Symptoms include sweating, trembling, confusion, and hunger. Treat promptly with fast-acting glucose
• Weight gain
• Stomach discomfort, nausea, or diarrhoea

Hypoglycaemia is more likely if you skip meals, exercise more than usual, or drink alcohol. Elderly patients and those with kidney impairment are at higher risk. Seek medical advice if you are having frequent hypoglycaemic episodes.

Hypoglycaemia risk with missed meals, alcohol, and excessive exercise. Educate patients on recognition and treatment of hypoglycaemia.

Contraindicated in type 1 diabetes, DKA, severe hepatic or renal impairment, and sulphonamide allergy.