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Zithromax

Zithromax

Active Ingredient: Azithromycin

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Medical Information

About This Medicine

Zithromax is the branded formulation of azithromycin, a macrolide antibiotic with an exceptionally long tissue half-life that allows short treatment courses. A three-day or single-dose course provides effective antibiotic concentrations at the site of infection for up to ten days. Azithromycin is used for respiratory tract infections, skin infections, chlamydia (single-dose treatment), and other susceptible infections.

Usage & Dosage

How to Take Azithromycin

For capsules, take one hour before or two hours after food for best absorption. Tablets and suspension can be taken with food. Complete the full course as prescribed.

The standard five-day course for most infections is 500 mg on the first day, followed by 250 mg once daily for four days. For a single-dose chlamydia treatment, 1 g is taken all at once. Take at the same time each day and do not skip doses, even if you feel better after a few days.

Standard: 500 mg on day 1, then 250 mg daily for 4 more days (total 1.5 g). Chlamydia: 1 g as a single dose. Community-acquired pneumonia: 500 mg daily for 3 days.

Side Effects

Common Side Effects

Common side effects include:

  • Nausea
  • Diarrhoea
  • Abdominal pain
  • Vomiting

These are usually mild and settle once the course is completed. Azithromycin can prolong the QT interval (a marker of electrical activity in the heart). While the risk is small at standard doses, caution is needed in patients with existing heart rhythm problems or those taking other QT-prolonging medicines. Tell your doctor if you experience palpitations or an irregular heartbeat.

Warnings & Precautions

Azithromycin can prolong the QT interval. Use with caution in patients with existing QT prolongation or taking other QT-prolonging drugs. Liver function monitoring may be needed for prolonged courses.

Contraindications

Contraindicated in known hypersensitivity to azithromycin, erythromycin, or other macrolides, and severe hepatic impairment.

Frequently Asked Questions

Why is the course only three days?
Azithromycin has an extremely long tissue half-life (approximately 68 hours). Three days of dosing creates tissue concentrations that persist at therapeutic levels for up to 10 days after the last dose, effectively providing the equivalent of a 10-day treatment course with other antibiotics.
Medically Reviewed

Dr. Ross Elledge

General Practitioner · General & Family Medicine

Verified Healthcare Professional

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