Zyban

Zyban contains bupropion, a noradrenaline and dopamine reuptake inhibitor originally developed as an antidepressant (Wellbutrin), repurposed as a smoking cessation aid. It reduces nicotine cravings and withdrawal symptoms through its action on dopaminergic reward pathways. Zyban approximately doubles quit rates compared to placebo and is particularly useful for smokers who are concerned about weight gain on quitting, as bupropion has a weight-neutral or mildly weight-reducing effect.

How to Take Zyban

Set your quit date and start Zyban (bupropion) one to two weeks before you plan to stop smoking. Take one 150 mg tablet once daily for the first six days, then increase to one tablet twice daily (at least eight hours apart). Do not take the second dose too close to bedtime, as Zyban commonly causes insomnia.

The recommended treatment course is seven to nine weeks. Continue taking Zyban after your quit date, it works by reducing cravings and the pleasurable effects of nicotine, and needs time to build up its effectiveness.

Days 1 to 6: 150 mg once daily. Day 7 onwards: 150 mg twice daily. Treatment duration: 7 to 9 weeks. Set a quit date within the first two weeks of treatment.

Common Side Effects

Common side effects include:

• Insomnia (the most common, avoid taking the second dose too late in the day)
• Dry mouth
• Headache
• Nausea
• Dizziness
• Taste disturbance

Zyban lowers the seizure threshold. It must not be used in people with a history of seizures, eating disorders (such as bulimia or anorexia), or those withdrawing from alcohol or benzodiazepines. Tell your doctor if you experience mood changes, agitation, or unusual thoughts during treatment.

Bupropion lowers the seizure threshold. Contraindicated in seizure disorders. Dose must not exceed 150 mg per dose or 300 mg per day. Avoid in patients with eating disorders (bulimia or anorexia). Monitor for mood changes.

Contraindicated in seizure disorders, CNS tumours, bulimia or anorexia nervosa, bipolar disorder, concurrent MAO inhibitor use, and abrupt withdrawal from alcohol or benzodiazepines.