Spedra Online UK

Spedra contains avanafil. This is a second-generation PDE5 inhibitor (a medicine that relaxes blood vessels). It was made specifically for erectile dysfunction (ED).

Among the PDE5 inhibitors you can get, avanafil is the most selective for PDE5 over other PDE types. This may explain its favourable side-effect profile.

Its main clinical advantage is how fast it works. Avanafil reaches its peak level in the blood in about 30-45 minutes. Some men in clinical studies saw it work as early as 15 minutes after taking it.

The effect lasts about 6-12 hours. In key phase III trials, avanafil clearly improved erectile function. It helped across all levels of ED severity and all causes.

This included men who are harder to treat, such as those with diabetes and those who had prostate surgery.

The BNF lists avanafil next to sildenafil, tadalafil, and vardenafil as a PDE5 inhibitor option for ED. Food has little effect on how fast or how well it is absorbed.

This makes it more practical to use than sildenafil.

Take one tablet about 15-30 minutes before you plan to have sex. Swallow it whole with water. You can take Spedra with or without food. High-fat meals do not change how it works in the body.

Do not take more than one dose in 24 hours. Avoid drinking too much alcohol, meaning more than 3 units. Too much alcohol can raise the risk of low blood pressure and make erections harder to get.

You still need sexual stimulation for avanafil to give you an erection. If you see no effect after several tries at the starting dose, speak to your prescriber.

They can discuss changing the dose or trying other options.

The recommended starting dose is 100 mg. Take it about 15-30 minutes before sex. Your prescriber may lower the dose to 50 mg or raise it to 200 mg.

This depends on how well it works for you and how well you tolerate it. Take it no more than once a day.

Some medicines are moderate CYP3A4 inhibitors, such as erythromycin, fluconazole, and verapamil. If you take these, the maximum dose is 100 mg. You must also wait at least 48 hours between doses.

Do not use avanafil with strong CYP3A4 inhibitors such as ketoconazole or ritonavir. If you are over 65, you do not need a different dose just because of your age. Mild liver problems need no change.

With moderate liver problems, the maximum is 100 mg. Avanafil is not recommended if you have severe liver or kidney problems.

These side effects follow the SmPC frequency groups, taken from key clinical trial data.

Common (≥1/100 to <1/10): Headache (about 10%), flushing (about 4%), a blocked nose (about 3%), and back pain.

Uncommon (≥1/1,000 to <1/100): Dizziness, drowsiness, blocked sinuses, indigestion, nausea, a pounding heartbeat, a fast heartbeat, hot flushes, vision changes, muscle pain, and tiredness.

Rare (≥1/10,000 to <1/1,000): Priapism (an erection lasting more than 4 hours), non-arteritic anterior ischaemic optic neuropathy (NAION), and sudden hearing loss in one or both ears.

Avanafil is highly selective for PDE5. Because of this, vision changes (which are PDE6-related) happen less often than with sildenafil.

Heart-related side effects in trials were about the same as with placebo. If you get priapism, seek emergency medical help straight away.

Do not take Spedra with organic nitrates or nitric oxide donors in any form. The mix can cause severe and possibly fatal low blood pressure.

If you need nitrates in an emergency, wait at least 12 hours after your last avanafil dose. This wait is shorter than with tadalafil because avanafil leaves the body faster.

Take care with alpha-blockers. You should be settled on your alpha-blocker treatment before you start avanafil, and use the lowest avanafil dose.

If you have heart risk factors, a heart check is advised before you start a PDE5 inhibitor. Avanafil has not been studied in people with inherited retinal disorders that get worse over time.

Take care if you are prone to priapism. This includes people with sickle cell disease, multiple myeloma, or leukaemia. Also take care if your penis has an unusual shape.

Do not take Spedra if any of the following apply to you. You are allergic to avanafil or any other ingredient. You take nitrates or nitric oxide donors.

You take strong CYP3A4 inhibitors, such as ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, nelfinavir, or saquinavir. You have had a recent stroke or heart attack.

You have very low blood pressure, below 90/50 mmHg. You have unstable angina. You have severe liver problems. You have severe kidney problems, with an eGFR below 30.

Spedra is also not for you if sex is not advisable because of your health.