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Cerazette

Cerazette Online UK

Active Ingredient: Desogestrel 75 micrograms
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The medical information on this site has been reviewed by Dr. Ross Elledge (GMC registered) and is provided for educational purposes. It does not replace a face-to-face consultation with your GP or specialist. Always follow the advice of your prescribing doctor and read the patient information leaflet supplied with your medication.

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Medical Information

About This Medicine

Cerazette is a progestogen-only pill (POP) containing desogestrel, prescribed for contraception.

Unlike older progestogen-only pills that rely primarily on thickening cervical mucus, Cerazette consistently inhibits ovulation in the majority of cycles, providing a level of contraceptive efficacy comparable to combined oral contraceptives.

Desogestrel at the 75-microgram dose used in Cerazette inhibits the luteinising hormone (LH) surge responsible for triggering ovulation.

It also thickens cervical mucus, making it impenetrable to sperm, and thins the endometrial lining. This triple mechanism makes it one of the most effective progestogen-only pills available.

Cerazette is taken continuously without a pill-free interval, meaning there is no scheduled withdrawal bleed.

Menstrual patterns may change; some women experience irregular bleeding, infrequent bleeding, or amenorrhoea.

Cerazette is suitable for women who cannot take oestrogen-containing contraceptives due to medical contraindications, oestrogen-related side effects, or personal preference, including women who are breastfeeding.

Usage & Dosage

Take one tablet daily at approximately the same time each day, without a break between packs. Swallow the tablet whole with water.

Cerazette has a 12-hour missed-pill window, which is more forgiving than traditional progestogen-only pills (which have a 3-hour window).

If you miss a pill by more than 12 hours, contraceptive protection may be reduced; take the missed pill as soon as possible and use barrier contraception for the next seven days.

Start the next pack immediately after finishing the current one.

One tablet (75 micrograms desogestrel) daily, taken continuously without interruption. There is no pill-free interval.

If starting for the first time, begin on the first day of menstruation for immediate protection. If starting on any other day, use additional barrier contraception for the first seven days.

After childbirth, Cerazette can be started on day 21 postpartum without additional precautions.

Side Effects

Common (1 in 10 to 1 in 100): altered bleeding pattern (irregular, frequent, prolonged, or absent periods), headache, mood changes, decreased libido, nausea, acne, breast tenderness, weight gain.

Uncommon (1 in 100 to 1 in 1,000): alopecia, fatigue, vaginal infection, dysmenorrhoea, ovarian cysts, vomiting, contact lens intolerance, skin rash.

Rare (1 in 1,000 to 1 in 10,000): erythema nodosum, ectopic pregnancy (lower rate than with no contraception).

Changes in bleeding pattern are the most common reason for discontinuation; amenorrhoea occurs in approximately 20% of users.

Warnings & Precautions

Cerazette does not protect against sexually transmitted infections. If you develop severe abdominal pain, consider the possibility of ectopic pregnancy and seek medical attention.

Functional ovarian cysts may develop and usually resolve spontaneously. Advise your prescriber if you have a history of breast cancer, liver disease, or unexplained vaginal bleeding.

Although the progestogen-only pill carries a lower risk of thromboembolism than combined pills, inform your doctor of any personal or family history of blood clots.

Contraindications

Cerazette is contraindicated in patients with known or suspected sex-steroid-sensitive malignancies, active venous thromboembolism, severe hepatic disease (including liver tumours), undiagnosed vaginal bleeding, and hypersensitivity to desogestrel or any excipient.

It should not be used during confirmed or suspected pregnancy.

Frequently Asked Questions

Will Cerazette stop my periods?
Approximately 20% of women using Cerazette experience amenorrhoea (no periods). Others may have irregular, infrequent, or lighter bleeding. This is a normal hormonal effect and is not harmful. Bleeding patterns often settle within the first three to six months.
Is Cerazette as effective as the combined pill?
Yes. Because Cerazette inhibits ovulation, unlike older progestogen-only pills, its efficacy is comparable to combined oral contraceptives (over 99% with perfect use). It also has a more forgiving missed-pill window of 12 hours.
Can I take Cerazette while breastfeeding?
Yes. Cerazette is a safe and commonly recommended contraceptive for breastfeeding women. It does not contain oestrogen, which can reduce milk supply. Small amounts of desogestrel pass into breast milk but are not considered harmful to the infant.
What should I do if I vomit after taking Cerazette?
If you vomit within three to four hours of taking a tablet, the active substance may not have been fully absorbed. Take another tablet as soon as possible. If vomiting continues, use barrier contraception until you have taken a tablet at the normal time without vomiting for 48 hours.
Does Cerazette cause weight gain?
Weight gain is listed as a common side effect. However, clinical studies show that average weight change is modest. Many factors influence body weight, and it can be difficult to attribute changes solely to the pill. Discuss concerns with your prescriber.
Medically Reviewed

Dr. Ross Elledge

Consultant Surgeon · Oral & Maxillofacial Surgery

Verified Healthcare Professional