Crestor Online UK

Crestor is the brand name for rosuvastatin calcium, a statin medication used to lower elevated cholesterol and other lipids in the blood.

It is prescribed for the treatment of primary hypercholesterolaemia, mixed dyslipidaemia, and homozygous familial hypercholesterolaemia when dietary measures and other non-pharmacological interventions have proved insufficient.

Rosuvastatin works by inhibiting HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis.

This reduction in intracellular cholesterol prompts the liver to increase the expression of LDL receptors on its surface, which in turn enhances the clearance of LDL cholesterol from the circulation.

Crestor is among the most potent statins available and can achieve LDL reductions of up to 55% at higher doses.

Beyond lipid lowering, Crestor has demonstrated cardiovascular benefit in clinical trials.

The JUPITER trial showed that rosuvastatin reduced the incidence of major cardiovascular events in individuals with elevated C-reactive protein even when LDL cholesterol levels were not markedly raised.

It is used as part of a comprehensive approach to cardiovascular risk management alongside lifestyle modification.

Take one Crestor tablet by mouth once daily at any time of day, with or without food. Swallow the tablet whole with water.

Maintaining a healthy diet low in saturated fat remains important during treatment.

Do not stop taking the medication without speaking to your doctor, as cholesterol levels will rise again if treatment is discontinued.

The usual starting dose is 5 mg to 10 mg once daily. Your doctor may increase this to 20 mg or, in selected cases, 40 mg after at least 4 weeks.

The 40 mg dose is reserved for patients with severe hypercholesterolaemia and high cardiovascular risk who have not achieved their target on 20 mg.

Dose adjustments may be required in patients of Asian ancestry and those with renal impairment.

Common (1 in 10 to 1 in 100): headache, myalgia, dizziness, constipation, nausea, abdominal pain. Uncommon (1 in 100 to 1 in 1,000): pruritus, rash, asthenia.

Rare (1 in 1,000 to 1 in 10,000): myopathy, pancreatitis, elevated creatine kinase. Very rare (less than 1 in 10,000): rhabdomyolysis, hepatitis, jaundice, peripheral neuropathy, memory impairment.

Report any unexplained muscle pain, tenderness, or weakness to your doctor, particularly if accompanied by malaise or fever.

Muscle effects including myalgia, myopathy, and rarely rhabdomyolysis may occur, particularly at higher doses and in combination with certain other medications.

Risk factors include renal impairment, hypothyroidism, personal or family history of muscular disorders, and concomitant use of fibrates or ciclosporin.

Liver function tests should be performed before starting treatment and periodically thereafter. Patients should be advised to report unexplained muscle symptoms promptly.

Diabetes mellitus has been reported in patients taking statins, particularly those with pre-existing risk factors.

Crestor is contraindicated in patients with active liver disease, unexplained persistent elevations in serum transaminases, severe renal impairment (for doses above 20 mg), and in patients with myopathy.

It must not be used during pregnancy or breastfeeding. The 40 mg dose is additionally contraindicated in patients with predisposing factors for myopathy or rhabdomyolysis.